Top-Notch Clean Hotels in Myrtle Beach

We checked thousands of reviews on and to find the best hotels for your stay
Go to Hotel List View map

Jacob Smith

Updated: 30 September 2024 · 2 min

Nestled along the picturesque coastline of South Carolina, Myrtle Beach stands as a premier vacation destination for those seeking sun, sand, and relaxation. As visitors flock to this charming city, one of the key considerations that can elevate their experience is choosing accommodation that offers not just comfort but also pristine cleanliness. With an array of lodging options available, discerning travelers can indulge in the luxury of staying at some of the cleanest hotels in Myrtle Beach, ensuring a stay that is not only memorable but also hygienic.

Imagine waking up to the sound of crashing waves and the gentle sea breeze, knowing that you are in a hotel that prioritizes cleanliness above all else. From meticulously sanitized rooms to stringent housekeeping protocols, the cleanest hotels in Myrtle Beach go the extra mile to provide guests with a safe and healthy environment. Whether you prefer a luxurious beachfront resort or a cozy boutique hotel, these top-rated accommodations offer a sanctuary where you can unwind and rejuvenate after a day of exploring the city's vibrant attractions.

Moreover, beyond the immaculate guest rooms and sparkling amenities, the cleanest hotels in Myrtle Beach boast exceptional service that caters to every guest's needs. From friendly staff members who ensure every corner is spotless to innovative cleaning technologies that maintain high standards of hygiene, these hotels set a new benchmark for cleanliness in the hospitality industry. When you choose to stay at one of these esteemed establishments, you not only invest in a comfortable stay but also in your peace of mind, knowing that your well-being is their top priority.
Show more + Show less -

Our Top 3

(Sorted by rating & number of reviews)

1. Anderson Ocean Club And Spa By Oceana Resorts
2. Palms Resort
3. Marina Inn At Grande Dunes

Cleanest Hotels in Myrtle Beach

Check Availability

Myrtle Beach
Mar 23, 2026 - Mar 24, 2026

Anderson Ocean Club And Spa By Oceana Resorts

8.5

Good

(2081 Reviews)

+ 302 photos
Experience a sanctuary of serenity and cleanliness at the Anderson Ocean Club and Spa, where every corner exudes a sense of pristine sophistication. This award-winning hotel boasts a serene spa, infinity pool, and stylish accommodations designed for the ultimate relaxation. Impeccable cleanliness is a hallmark of this resort, reflecting its commitment to providing a safe and hygienic environment for guests.
Address: 2600 North Ocean Boulevard
Rating: Good 8.5 (2081 Reviews)
Rooms: 304
Price: From 124$

Cleanest Hotels in Myrtle Beach

Palms Resort

8.9

Good

(7 Reviews)

+ 212 photos
Nestled on the golden shores of Myrtle Beach is a beacon of elegance and cleanliness. With meticulous attention to detail in housekeeping and sanitization practices, this upscale resort sets the standard for cleanliness in hospitality. Guests are treated to spacious suites, stunning ocean views, and a range of amenities that epitomize luxury and comfort.
Address: 2500 N. Ocean Blvd.
Rating: Good 8.9 (7 Reviews)
Rooms: 51
Price: From 121$

Marina Inn At Grande Dunes

8.9

Good

(729 Reviews)

+ 203 photos
Indulge in a blend of luxury and cleanliness at the Marina Inn at Grande Dunes, a waterfront oasis that exudes tranquility and elegance. From the beautifully appointed rooms to the attentive service, every aspect of this hotel radiates a commitment to cleanliness and guest satisfaction. With stunning views of the marina and an array of upscale amenities, this resort offers a pristine retreat for those seeking the finest in hospitality.
Address: 8121 Amalfi Place
Rating: Good 8.9 (729 Reviews)
Rooms: 29
Price: From 139$